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<< JRScience Home     Volume 16 No.1   June, 2005    << Back to Volume Home

IN-VITRO STUDY OF PERCUTANEOUS ABSORPTION OF DICLOFENAC IN THE PRESENCE OF SODIUM LAURYL SULPHATE THROUGH RABBIT SKIN

 Syed Nisar Hussain Shah, Mahboob Rabbani and Muhammad Fakhruddin Amir

Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.

Abstract: In the present study, effect of various concentrations of Sodium Lauryl Sulphate (SLS) as an enhancer on transdermal absorption of Diclofenac diethylamine through hairless rabbit skin was evaluated in-vitro. From the data, SLS shows that the smallest lag time gives a picture about its rapid enhancing effect. The permeability co-efficient and flux rate calculated for Diclofenac in the presence of SLS as an enhancer shows that the penetration of drug through hairless rabbit skin has been significantly increased.  

Keywords: Diclofenac, enhancer, topically, transdermal.