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<< JRScience Home     Volume 15 No.4    December, 2004    << Back to Volume Home



  Kalsoom Farzana*, Shazia Batool, Farzana Jabeen and Syed Nisar Hussain Shah

Department of Pharmacy, Bahauddin Zakariya University, Multan.

Abstract: A prospective bactericidal activity of various market soaps were performed against Gram-negative bacteria, i.e. Salmonella typhi. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined by the NCCLS reference microdilution technique. The minimum inhibitory concentrations (MICs) of Johnson and Johnson baby soap and Dettol soap were 1024 mg ml-1 and 2048 mg ml-1 respectively. Whereas, the MIC value was 3072 mg ml-1 for Safeguard. Phenol and Sufi soap had similar activity against S. typhi with MIC of 6144 mg ml-1. Lux and Lifebuoy white had higher inhibitory activity against Salmonella typhi with MIC of 12288 mg ml-1, whereas Lifebuoy red had 8192 mg ml-1. The bactericidal activity of these soaps was in decreasing order as Sunlite, Lifebuoy white, Lux, Lifebuoy red, Sufi soap, Phenol, Safeguard, Dettol and Johnson and Johnson baby soap respectively. Moreover, the minimum inhibitory concentration of all soaps does not vary significantly against S. typhi. However, the minimum bactericidal concentration was significantly different among all the market soaps.

Keywords: Bactericidal activity, inhibition, Salmonella typhi, soaps.