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STUDY OF PERCUTANEOUS ABSORPTION OF DICLOFENAC DIETHYLAMINE IN THE PRESENCE OF CETRIMIDE THROUGH HAIRLESS RABBIT SKIN
Syed Nisar Hussain Shah, Mahboob Rabbani and Muhammad Fakhruddin Amir
Faculty of Pharmacy, Bahauddin Zakariya University, Multan-Pakistan.
Abstract: In the present study, the effect of Cetrimide as an enhancer on transdermal absorption of 1% diclofenac diethylamine (Non-steroidal Anti-inflammatory Drug) through hairless rabbit skin was evaluated in-vitro study at various concentrations to improve the skin permeability. From the data, Cetrimide shows the small lag time which gives a picture about its enhancing effect. The permeability co-efficient and flux rate calculated for diclofenac diethylamine in the presence of Cetrimide shows that the penetration of drug through hairless rabbit skin has been significantly increased.
Keywords: Diclofenac, enhancer, skin permeability, topically, transdermal.