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SELECTIVE INHIBITION OF PAF-INDUCED HUMAN PLATELET AGGREGATION BY GARLIC
Sheikh Arshad Saeed* and Imran
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
Garlic exudate (0.2-2.5 mg) prepared by squeezing fresh garlic cloves inhibited platelet aggregation induced by platelet activating factor (PAF) in a dose-dependent manner. No inhibition of aggregation was observed when adenosine-5'-diphosphate (ADP) or arachidonic acid (AA) were used as aggregating agents. This selective effect of garlic against PAF-induced aggregation was also seen with aqueous or alcoholic garlic extracts. These results suggest that PAF antagonists are present in garlic.
Keywords: Garlic, human platelet aggregation, platelet activating factor (PAF).